Title: Edrecolomab
CAS Registry Number: 156586-89-9
CAS Name: Anti-(human colon cancer tumor-associated antigen) immunoglobulin G2a (mouse monoclonal 17-1ag2a-chain) disulfide with mouse monoclonal 17-1A light chain, dimer
Additional Names: 17-1A antibody
Trademarks: Panorex (Centocor)
Literature References: Murine monoclonal IgG2a antibody directed against the cell surface glycoprotein CO17-1A, a human tumor associated antigen expressed on malignant and normal epithelial cells. Prepn: M. Herlyn et al., Proc. Natl. Acad. Sci. USA 76, 1438 (1979). Pharmacology: D. Herlyn, H. Koprowski, ibid. 79, 4761 (1982). Clinical studies in colorectal cancer: G. Riethmüller et al., Lancet 343, 1177 (1994); eidem, J. Clin. Oncol. 16, 1788 (1998). Review of prepn and pharmacology: A. H. Ross et al., Immunol. Ser. 43, 107-122 (1989); and clinical experience: J. C. Adkins, C. M. Spencer, Drugs 56, 619-626 (1998).
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Monoclonal Antibodies. |