Erabutoxins

Literature References: Neurotoxic principles isolated from venom of the sea-snake, Laticauda semifasciata (in Japanese, erabu-umihebi). Their action on post-synaptic membrane blocks neuromuscular transmission. Separation and crystn of erabutoxins A and B: Tamiya, Arai, Biochem. J. 99, 624 (1966). Structures are single polypeptide chains containing 62 amino acid residues with four S-S bridges, erabutoxin A differing from erabutoxin B only in the amino acid residue at position 26: Sato, Tamiya, ibid. 122, 453 (1971); Endo et al., ibid. 463. Isoln and structure of the minor component, erabutoxin C: Tamiya, Abe, ibid. 130, 547 (1972). Corrected amino acid sequences: N. Maeda, N. Tamiya, Biochem. J. 167, 289 (1977). Three-dimensional structure of B, description of active site: B. W. Low, Adv. Cytopharmacol. 3, 141 (1979). Molecular conformation: M. R. Kimball et al., Biochem. Biophys. Res. Commun. 88, 950 (1979); F. Inagaki et al., Eur. J. Biochem. 109, 129 (1980). Raman spectra: T. Takamatsu et al., Biochim. Biophys. Acta 622, 189 (1980). Immunological studies: A. Tatsuya et al., Toxicon 17, 571 (1979), C.A. 92, 141459t (1980). Effect on transmission in autonomic ganglia: V. A. Chiappinelli et al., Brain Res. 211, 107 (1981).