Title: Factor IX
CAS Registry Number: 9001-28-9
CAS Name: Blood-coagulation factor IX
Additional Names: Christmas factor; PTC; plasma thromboplastin component; antihemophilic factor B; autoprothrombin II
Literature References: A plasma and serum glycoprotein that participates in the middle phases of blood coagulation. Activated by factor XI and Ca2+. Interacts then with factor VIII, Ca2+, and phospholipid to form the complex which converts factor X into factor Xa. Isoln and characterization of bovine factor IX: K. Fujikawa et al., Biochemistry 12, 4938 (1973); K. Fujikawa, E. W. Davie, Methods Enzymol. 45B, 74 (1976). Deficiency results in a congenital bleeding disorder known as Christmas disease or hemophilia B. Review: Macfarlane in Thrombolytic Activity and Related Phenomena, I. S. Wright et al., Eds. (Schattauer-Verlag, Stuttgart, 1961) pp 408-415; B. N. Bouma, J. A. Van Mourik, Haemostasis: Biochemistry, Physiology & Pathology, D. Ogston, B. Bennett, Eds. (Wiley-Interscience, New York, 1977) pp 56-77.
Derivative Type: Factor IX complex (human)
Trademarks: Konyne (Miles); Profilnine (Alpha Ther.); Proplex T (Baxter)
Properties: A mixture of human factors II, VII, IX, and X.
Derivative Type: Factor IX (human)
Trademarks: AlphaNine (Alpha Ther.); Mononine (ZLB Behring)
Therap-Cat: Hemostatic.
Keywords: Hemostatic. |