Title: Flupentixol
CAS Registry Number: 2709-56-0
CAS Name: 4-[3-[2-(Trifluoromethyl)-9H-thioxanthen-9-ylidene]propyl]-1-piperazineethanol
Additional Names: 2-trifluoromethyl-9-[3-[4-(b-hydroxyethyl)-1-piperazinyl]propylidene]thioxanthene; flupenthixol
Manufacturers' Codes: N-7009; LC-44
Molecular Formula: C23H25F3N2OS
Molecular Weight: 434.52
Percent Composition: C 63.58%, H 5.80%, F 13.12%, N 6.45%, O 3.68%, S 7.38%
Literature References: Neuroleptic agent related structurally to thiothixene, q.v. Prepn: P. N. Craig, C. L. Zirkle, US 3282930 (1966 to SKF). Prepn of cis- and trans-forms: GB 925538 (1963 to SKF); P. V. Petersen, T. Ammitzboll, US 3681346 (1972 to Kefalas). Metabolism of decanoate: A. Jorgensen et al., Acta Pharmacol. Toxicol. 29, 339 (1971). a-Flupentixol, the cis-isomer, shows greater pharmacological activity than b-flupentixol, the trans-isomer: I. Moller Nielsen et al., Acta Pharmacol. Toxicol. 33, 353 (1973). X-ray crystallography of isomers: M. L. Post et al., Nature 256, 342 (1975).
Derivative Type: Dihydrochloride
CAS Registry Number: 2413-38-9
Trademarks: Emergil (Labaz); Fluanxol (Lundbeck); Siplarol (Erba); Metamin (Takeda)
Molecular Formula: C23H25F3N2OS.2HCl
Molecular Weight: 507.44
Percent Composition: C 54.44%, H 5.36%, F 11.23%, N 5.52%, O 3.15%, S 6.32%, Cl 13.97%
Derivative Type: Decanoate
CAS Registry Number: 30909-51-4
Manufacturers' Codes: Lu-5-110
Trademarks: Depixol (Lundbeck); Fluanxol Dépot (Lundbeck); Viscoleo (Lundbeck)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Thioxanthenes. |