Title: Hanatoxins
CAS Registry Number: 253687-10-4
Additional Names: HaTx
Literature References: Peptide toxins isolated from the venom of the Chilean tarantula, Phrixotrichus spatulata, originally named Grammostola spatulata; modifies voltage-dependent K+ channels by shifting channel opening to more depolarized voltages. 35 amino acids long with 3 disulfide linkages, mol wt ~4.1 kDa. Isoln and characterization: K. J. Swartz, R. MacKinnon, Neuron 15, 941 (1995). Mechanism of action and identification of receptor binding sites: eidem, ibid. 18, 665, 675 (1997). Use as probe for determn of channel structure: Y. Li-Smerin, K. J. Swartz, Proc. Natl. Acad. Sci. USA 95, 8585 (1998); V. Ruta et al., Nature 422, 180 (2003). Reagent for measurement of channel current in myocytes: H. M. Himmel et al., Am. J. Physiol. 277, H107 (1999).
Derivative Type: Hanatoxin 1
CAS Registry Number: 281212-01-9 (native); 170780-00-4 (reduced)
Additional Names: HaTx1
Literature References: NMR determn of 3d-structure: H. Takahashi et al., J. Mol. Biol. 297, 771 (2000).
Derivative Type: Hanatoxin 2
CAS Registry Number: 170780-01-5 (reduced)
Additional Names: HaTx2
Use: Inhibition of voltage-gated K+ channels. |