Title: Iobitridol
CAS Registry Number: 136949-58-1
CAS Name: N,N¢-Bis(2,3-dihydroxypropyl)-5-[[3-hydroxy-2-(hydroxymethyl)-1-oxopropyl]amino]-2,4,6-triiodo-N,N¢-dimethyl-1,3-benzenedicarboxamide
Additional Names: 5-[3-hydroxy-2-(hydroxymethyl)-propionamido]-N,N¢-dimethyl-N,N¢-bis-(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide
Trademarks: Xenetix (Guerbet)
Molecular Formula: C20H28I3N3O9
Molecular Weight: 835.16
Percent Composition: C 28.76%, H 3.38%, I 45.59%, N 5.03%, O 17.24%
Literature References: Nonionic, monomeric, low-osmolality x-ray contrast medium for urography and angiography. Prepn: M. Schaefer et al., EP 437144; eidem, US 5043152 (both 1991 to Guerbet). Biodistribution studies: P. Bourrinet et al., Invest. Radiol. 29, 1057 (1994). HPLC determn in biological fluids: idem et al., J. Chromatogr. B 670, 369 (1995). Toxicology: A.-M. Donadieu et al., Acta Radiol. 37, Suppl. 400, 17 (1996). Series of articles on pharmacology, pharmacokinetics and clinical studies: ibid. 1-92.
Properties: Hydrophilic. Log P (octanol/water): -2.63 at 37°. LD50 in male, female mice (g I/kg): 16.8, 16.6 i.v. (Donadieu).
Log P: Log P (octanol/water): -2.63 at 37°
Toxicity data: LD50 in male, female mice (g I/kg): 16.8, 16.6 i.v. (Donadieu)
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium). |