Title: Iohexol
CAS Registry Number: 66108-95-0
CAS Name: 5-[Acetyl(2,3-dihydroxypropyl)amino]-N,N¢-bis(2,3-dihydroxypropyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
Additional Names: N,N¢-bis(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-2,4,6-triiodoisophthalamide
Manufacturers' Codes: Win-39424; Compd 545
Trademarks: Omnipaque (GE Healthcare)
Molecular Formula: C19H26I3N3O9
Molecular Weight: 821.14
Percent Composition: C 27.79%, H 3.19%, I 46.36%, N 5.12%, O 17.54%
Literature References: Nonionic radio-contrast medium. Prepn: V. Nordal, H. Holtermann, DE 2726196; eidem, US 4250113 (1977, 1981 both to Nyegaard). HPLC-UV determn in plasma: R. S. Soman et al., J. Chromatogr. B 816, 339 (2005). Pharmacology and toxicology: Acta Radiol. Suppl. 362, 1-134 (1980). Acute toxicity: S. Salvesen, ibid. 73. Fibrillatory potential in dogs: G. L. Wolf et al., Invest. Radiol. 16, 320 (1981). Comparative clinical studies in coronary angiography: G. B. J. Mancini et al., Am. J. Cardiol. 51, 1218 (1983); I. D. Sullivan et al., Br. Heart J. 51, 643 (1984); M. A. Bettmann et al., Radiology 153, 583 (1984). Review: T. Almén, Acta Radiol. Suppl. 366, 9-19 (1983).
Properties: Crystals from butanol, mp 174-180°. Sol in water. Stable in aqueous solutions. Viscosity (cP): 6.2 at 37°; 12.6 at 20° (c = 200 mg Iodine/ml). LD50 in male, female rats, mice (g Iodine/kg): 15.0, 12.3, 24.3, 25.1 i.v. (Salvesen).
Melting point: mp 174-180°
Toxicity data: LD50 in male, female rats, mice (g Iodine/kg): 15.0, 12.3, 24.3, 25.1 i.v. (Salvesen)
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium). |