Title: Ioxaglic Acid
CAS Registry Number: 59017-64-0
CAS Name: 3-[[[[3-(Acetylmethylamino)-2,4,6-triiodo-5-[(methylamino)carbonyl]benzoyl]amino]acetyl]amino]-5-[[(2-hydroxyethyl)amino]carbonyl]-2,4,6-triiodobenzoic acid
Additional Names: N-(2-hydroxyethyl)-2,4,6-triiodo-5-[2-[2,4,6-triiodo-3-(N-methylacetamido)-5-(methylcarbamoyl)benzamido]acetamido]isophthalamic acid
Manufacturers' Codes: P-286
Molecular Formula: C24H21I6N5O8
Molecular Weight: 1268.88
Percent Composition: C 22.72%, H 1.67%, I 60.01%, N 5.52%, O 10.09%
Literature References: Ionic contrast medium of low osmolality. Prepn: G. Tilly et al., DE 2523567; eidem, US 4014986 (1975, 1977 both to Guerbet). Effect on peripheral arterial blood flow in dogs: R. M. Steiner et al., Clin. Radiol. 31, 621 (1980). Effect on thyroid function: R. G. Grainger, G. W. Pennington, Br. J. Radiol. 54, 768 (1981). Clinical study in femoral angiography: S. Suzuki et al., Acta Radiol. 23, 87 (1982); in cardiac radiology: R. L. Feldman, Am. J. Cardiol. 61, 1334 (1988). Toxicity study: M. Sovak et al., Invest. Radiol. 16, 438 (1981). Mutation study: W. Hadnagy et al., Mutat. Res. 104, 249 (1982).
Derivative Type: Mixture of meglumine and sodium salts
CAS Registry Number: 76820-74-1
Manufacturers' Codes: MP-302
Trademarks: Hexabrix (Guerbet)
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium). |