Title: Ioxilan
CAS Registry Number: 107793-72-6
CAS Name: 5-[Acetyl(2,3-dihydroxypropyl)amino]-N-(2,3-dihydroxypropyl)-N¢-(2-hydroxyethyl)-2,4,6-triiodo-1,3-benzenedicarboxamide
Additional Names: N-(2,3-dihydroxypropyl)-5-[N-(2,3-dihydroxypropyl)acetamido]-N¢-(2-hydroxyethyl)-2,4,6-triiodoisophthalamide; ioxitol
Trademarks: Oxilan (Cook Imaging)
Molecular Formula: C18H24I3N3O8
Molecular Weight: 791.11
Percent Composition: C 27.33%, H 3.06%, I 48.12%, N 5.31%, O 16.18%
Literature References: Nonionic iodinated contrast medium. Prepd not claimed: M. Sovak, R. Ranganathan, WO 8700757; eidem, US 5035877 (1987, 1991 both to Cook Imaging). HPLC analysis of isomers: S. J. Foster, M. Sovak, Invest. Radiol. 23, Suppl. 1, S106 (1988). Pharmacology: R. W. Katzberg et al., ibid. 25, 46 (1990). Clinical evaluation: M. R. Callantine et al., ibid. Suppl. 1, S107; C. L. McIntosh, R. Reed, ibid. 29, Suppl. 2, S40 (1994). Brief review of physical properties: M. Sovak, ibid. 23, Suppl. 1, S79-S83 (1988).
Properties: Sol in water. Osmolality (mOsm/kg H2O): 690 (c = 350 mgI/ml); 570 (c = 300 mgI/ml). Viscosity (37°): 4.6-4.7 cP (c = 300 mgI/ml).
Therap-Cat: Diagnostic aid (radiopaque medium).
Keywords: Diagnostic Aid (Radiopaque Medium). |