Title: Ipidacrine
CAS Registry Number: 62732-44-9
CAS Name: 2,3,5,6,7,8-Hexahydro-1H-cyclopenta[b]quinolin-9-amine
Additional Names: 9-amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinoline; amiridin
Molecular Formula: C12H16N2
Molecular Weight: 188.27
Percent Composition: C 76.55%, H 8.57%, N 14.88%
Literature References: Cholinesterase inhibitor; structural analog of tacrine. Prepn: A. V. Upadysheva et al., Khim. Farm. Zh. 11, 40 (1977), C.A. 86, 189676q (1977). Prepn of the hydrochloride monohydrate: E. F. Levretskaya et al., DE 3231571; eidem, US 4550113 (1984, 1985 both to Sci. Res. Inst. Biol. Test. Chem. Compds). Neuropharmacology: T. Nabeshima et al., Eur. J. Pharmacol. 154, 263 (1988). Anticholinesterase activity: S. Shibanoki et al., Pharmacol. Biochem. Behav. 39, 499 (1991). Clinical evaluation in Alzheimer's disease: E. E. Bukatina et al., Neurosci. Behav. Physiol. 23, 83 (1993).
Derivative Type: Hydrochloride
CAS Registry Number: 90043-86-0; 118499-70-0 (monohydrate)
Manufacturers' Codes: NIK-247
Molecular Formula: C12H16N2.HCl
Molecular Weight: 224.73
Percent Composition: C 64.13%, H 7.62%, N 12.47%, Cl 15.78%
Properties: Prepd as the monohydrate. White or slightly creamy, odorless powder. Readily sol in water, dil acids; slowly sol in ethanol. Practically insol in acetone, ether, chloroform.
Therap-Cat: Nootropic.
Keywords: Cholinesterase Inhibitor; Nootropic.
Status: This monograph has been retired and is no longer subject to revision or update. |