Title: Isosorbide
CAS Registry Number: 652-67-5
CAS Name: 1,4:3,6-Dianhydro-D-glucitol
Additional Names: 1,4:3,6-dianhydrosorbitol
Manufacturers' Codes: AT-101; NSC-40725
Trademarks: Hydronol (Stuart); Ismotic (Alcon); Isobide (Nikken)
Molecular Formula: C6H10O4
Molecular Weight: 146.14
Percent Composition: C 49.31%, H 6.90%, O 43.79%
Literature References: Prepd by acid dehydration of D-glucitol: Haworth, Wiggins, GB 600870 (1948). Purification: Hartmann, US 3160641 (1964 to Atlas Chemical Industries). Review of prepn, structure, properties: Wiggins, Adv. Carbohydr. Chem. 5, 191-228 (1950). Stereochemistry: Cope, Shen, J. Am. Chem. Soc. 78, 3177 (1956). Conformation studies: Hopton, Thomas, Can. J. Chem. 47, 2395 (1969). Pharmacodynamics in man: Nodine et al., Clin. Pharmacol. Ther. 14, 196 (1973).
Properties: Crystals, mp 61-64°. [a]D +44°.
Melting point: mp 61-64°
Optical Rotation: [a]D +44°
Therap-Cat: Diuretic.
Keywords: Diuretic. |