Title: Laidlomycin
CAS Registry Number: 56283-74-0
CAS Name: 16-Deethyl-3-O-demethyl-16-methyl-3-O-(1-oxopropyl)monensin
Molecular Formula: C37H62O12
Molecular Weight: 698.88
Percent Composition: C 63.59%, H 8.94%, O 27.47%
Literature References: Polyether ionophore antibiotic; structurally related to monensin, q.v. Isoln from Streptomyces spp. and antimicrobial activity: F. Kitame et al., J. Antibiot. 27, 884 (1974). Structure determn: F. Kitame, N. Ishida, ibid. 29, 759 (1976). Prepn of esters: A. F. Kluge, R. D. Clark, EP 24189 (1981 to Syntex). 13C-NMR study and enhancement of biological activities: R. D. Clark et al., J. Antibiot. 35, 1527 (1982). Mechanism of action study: U. Gräfe et al., J. Basic Microbiol. 29, 391 (1989). HPLC determn in fermentation broth: M. Beran et al., Chromatographia 31, 603 (1991). Effect on cattle growth: M. T. Van Koevering et al., 1991 Animal Science Research Report (Agricultural Experiment Station, Oklahoma State University, Stillwater, OK, 1991) 241; M. L. Galyean et al., J. Anim. Sci. 70, 2950 (1992).
Properties: Colorless prisms from chloroform-ethyl acetate. mp 151-153°. [a]D22 +51.3° (c=0.2 in CHCl3). Sol in CHCl3, acetone, alcohols. Insol in water, n-hexane. LD50 in mice (mg/kg): 5 i.p.; 1 i.v.; 2.5 s.c. (Kitame).
Melting point: mp 151-153°
Optical Rotation: [a]D22 +51.3° (c=0.2 in CHCl3)
Toxicity data: LD50 in mice (mg/kg): 5 i.p.; 1 i.v.; 2.5 s.c. (Kitame)
Derivative Type: Propionate potassium
CAS Registry Number: 84799-02-0
Manufacturers' Codes: RS-11988
Trademarks: Cattlyst (Syntex)
Molecular Formula: C40H65KO13
Molecular Weight: 793.03
Percent Composition: C 60.58%, H 8.26%, K 4.93%, O 26.23%
Properties: mp 190-192°.
Melting point: mp 190-192°
Therap-Cat-Vet: Growth promotant. |