Title: Merimepodib
CAS Registry Number: 198821-22-6
CAS Name: [[3-[[[[3-Methoxy-4-(5-oxazolyl)phenyl]amino]carbonyl]amino]phenyl]methyl] carbamic acid (3S)-tetrahydro-3-furanyl ester
Manufacturers' Codes: VX-497
Molecular Formula: C23H24N4O6
Molecular Weight: 452.46
Percent Composition: C 61.05%, H 5.35%, N 12.38%, O 21.22%
Literature References: Inosine 5ยข-monophosphate dehydrogenase (IMPDH) inhibitor. Prepn (stereochemistry unspecified): D. M. Armistead et al., WO 9740028; eidem, US 5807876 (1997, 1998 both to Vertex). In vitro antiviral spectrum: W. Markland et al., Antimicrob. Agents Chemother. 44, 859 (2000); immunosuppressive activity: J. Jain et al., J. Pharm. Sci. 90, 625 (2001). Clinical evaluation in hepatitis C: J. G. McHutchison et al., Antiviral Ther. 10, 635 (2005). Review of structure-activity and mechanism of action: M. D. Sintchak, E. Nimmesgern, Immunopharmacology 47, 163-184 (2000); of development and therapeutic potential: G. Tossing, IDrugs 6, 372-376 (2003).
Therap-Cat: Antiviral.
Keywords: Antiviral. |