Title: Moquizone
CAS Registry Number: 19395-58-5
CAS Name: 2,3-Dihydro-1-[(4-morpholinyl)acetyl]-3-phenyl-4(1H)-quinazolinone
Manufacturers' Codes: Rec-14-0127
Molecular Formula: C20H21N3O3
Molecular Weight: 351.40
Percent Composition: C 68.36%, H 6.02%, N 11.96%, O 13.66%
Literature References: Prepn: G. Bonola et al., J. Med. Chem. 11, 1136 (1968); eidem, ZA 68 03948 C.A. 71, 81406c (1969) and CH 474524; eidem, US 3637681 (1968, 1969, 1972 all to SECEPH). Pharmacology: I. Setnikar et al., Arzneim.-Forsch. 22, 1894 (1972). Toxicology: I. Setnikar, V. De Fina, Toxicol. Appl. Pharmacol. 16, 571 (1970). Review of pharmacological and clinical aspects: F. Grossi, S. Spada, Clin. Ter. 50, 203 (1969).
Properties: Crystals from isopropanol, mp 135-137°. Crystals from ethyl acetate or benzene-petr ether, mp 128-130°.
Melting point: mp 135-137°; mp 128-130°
Derivative Type: Hydrochloride
CAS Registry Number: 19395-78-9
Trademarks: Peristil (Recofarma)
Molecular Formula: C20H21N3O3.HCl
Molecular Weight: 387.86
Percent Composition: C 61.93%, H 5.72%, N 10.83%, O 12.38%, Cl 9.14%
Properties: Crystals from ethanol-ether, mp 210-214°. Solubility in water (25°): 12.2 g/100 ml. LD50 in mice, rats, rabbits (mg/kg): 1155, 2135, 1650 orally; 237, 146, 180 i.v.; in mice (mg/kg): 774 s.c., 559 i.p. (Setnikar, De Fina).
Melting point: mp 210-214°
Toxicity data: LD50 in mice, rats, rabbits (mg/kg): 1155, 2135, 1650 orally; 237, 146, 180 i.v.; in mice (mg/kg): 774 s.c., 559 i.p. (Setnikar, De Fina)
Therap-Cat: Choleretic.
Keywords: Choleretic.
Status: This monograph has been retired and is no longer subject to revision or update. |