Title: N-(4-Aminobenzoyl)-L-glutamic acid
CAS Registry Number: 4271-30-1
Additional Names: N-(p-aminobenzoyl)glutamic acid; PABG
Molecular Formula: C12H14N2O5
Molecular Weight: 266.25
Percent Composition: C 54.13%, H 5.30%, N 10.52%, O 30.05%
Literature References: Catabolite of folate. Prepn: J. Van der Scheer, K. Landsteiner, J. Immunol. 29, 371 (1935). Improved synthesis: A. P. Reddy, C. P. R. Reddy, Org. Prep. Proced. Int. 22, 117 (1990); P. Maunder et al., J. Chem. Soc. Perkin Trans. 1 1311 (1999). HPLC determn: B. A. Allen, R. A. Newman, J. Chromatogr. 190, 241 (1980); densitometric determn in folic acid tablets: J. Krzek, A. Kwiecien, J. Pharm. Biomed. Anal. 21, 451 (1999). Use as marker of folate degradation: J. McPartlin, J. Scott, Methods Enzymol. 281, 70 (1997); of turnover in pregnant women: J. F. Gregory, III et al., J. Nutr. 131, 1928 (2001).
Properties: Off white solid, mp 173-174° (dec). [a]D23 -15° (c = 2 in 0.1 M HCl).
Melting point: mp 173-174° (dec)
Optical Rotation: [a]D23 -15° (c = 2 in 0.1 M HCl)
Use: Marker in folate metabolism studies. |