Title: Nafamostat
CAS Registry Number: 81525-10-2
CAS Name: 4-[(Aminoiminomethyl)amino]benzoic acid 6-(aminoiminomethyl)-2-naphthalenyl ester
Additional Names: 6-amidino-2-naphthyl-4-guanidinobenzoate; nafamstat
Molecular Formula: C19H17N5O2
Molecular Weight: 347.37
Percent Composition: C 65.69%, H 4.93%, N 20.16%, O 9.21%
Literature References: Non-peptide protease inhibitor. Prepn: S. Fujii et al., EP 48433; eidem, US 4454338 (1982, 1984 both to Torii & Co.); T. Aoyama et al., Chem. Pharm. Bull. 33, 1458 (1985). Inhibitory effects on trypsin, thrombin, kallikrein, plasmin and complement-mediated hemolysis: S. Fujii, Y. Hitomi, Biochim. Biophys. Acta 661, 342 (1981); T. Aoyama et al., Jpn. J. Pharmacol. 35, 203 (1984). Effect in experimental acute pancreatitis in rats: M. Iwaki et al., ibid. 41, 155 (1986). Spectrofluorometric determn in biological material: T. Aoyama et al., Chem. Pharm. Bull. 33, 2142 (1985). Clinical anti-complement activity: Y. Miyamoto et al., Trans. Am. Soc. Artif. Intern. Organs 31, 508 (1985).
Derivative Type: Dimethanesulfonate
CAS Registry Number: 82956-11-4
Additional Names: Nafamostat mesylate
Manufacturers' Codes: FUT-175
Trademarks: Futhan (Torii)
Molecular Formula: C19H17N5O2.2CH3SO3H
Molecular Weight: 539.58
Percent Composition: C 46.74%, H 4.67%, N 12.98%, O 23.72%, S 11.89%
Properties: Crystals from ethyl ether, mp 217-220° (Fujii). Also reported as colorless powder from water, mp 260° (dec) (Aoyama).
Melting point: mp 217-220° (Fujii); mp 260° (dec) (Aoyama)
Therap-Cat: Enzyme inhibitor (protease).
Keywords: Protease Inhibitor. |