Neurotensin

Literature References: A basic tridecapeptide, found in mammalian brain and gut, having a wide variety of hormone-like activities. Neurotensin has been shown to induce hypotension in the rat, to stimulate contraction of guinea pig ileum and rat uterus, and to cause relaxation of rat duodenum. There is also evidence that it acts as a CNS neurotransmitter. Isoln from bovine hypothalamus: R. Carraway, S. Leeman, J. Biol. Chem. 248, 6854 (1973). Amino acid sequence of bovine neurotensin: eidem, ibid. 250, 1907 (1975). Synthesis: eidem, ibid. 1912; K. Kitagawa et al., Chem. Pharm. Bull. 24, 2692 (1976); H. Yajima et al., Int. J. Pept. Protein Res. 14, 169 (1979). Isoln, amino acid sequence of chicken neurotensin: R. Carraway, Y. M. Bhatnagar, Peptides 1, 167 (1980). Synthesis: H. Yajima et al., Chem. Pharm. Bull. 29, 2587 (1981). Radioimmunoassay and differential distribution of bovine neurotensin in CNS, small intestine, and stomach: R. Carraway, S. Leeman, J. Biol. Chem. 251, 7035, 7045 (1976). CNS effects: C. B. Nemeroff et al., Brain Res. 128, 485 (1977). Receptor binding in brain: G. R. Uhl et al., ibid. 130, 299 (1977). Pharmacokinetics and effect on gastrointestinal and pituitary hormones in man: A. M. Blackburn et al., J. Clin. Endocrinol. Metab. 51, 1257 (1980). Reviews of biological activity: G. R. Uhl, S. H. Snyder, Adv. Biochem. Psychopharmacol. 28, 87-106 (1981); D. R. Brown, R. J. Miller, Annu. Rep. Med. Chem. 17, 271-280 (1982). Book: Ann. N.Y. Acad. Sci. 400, entitled "Neurotensin, a Brain and Gastrointestinal Peptide", C. B. Nemeroff, A. J. Prange, Eds. (1982) pp 1-444.