Title: Perimethazine
CAS Registry Number: 13093-88-4
CAS Name: 1-[3-(2-Methoxy-10H-phenothiazin-10-yl)-2-methylpropyl]-4-piperidinol
Additional Names: 2-methoxy-10-[2-methyl-3-(4-hydroxypiperidino)propyl]phenothiazine; 3-methoxy-10-[3-(4-hydroxypiperidyl)-2-methylpropyl]phenothiazine; perimetazine
Manufacturers' Codes: RP-9159; AN-1317
Trademarks: Leptryl (Bellon)
Molecular Formula: C22H28N2O2S
Molecular Weight: 384.53
Percent Composition: C 68.72%, H 7.34%, N 7.29%, O 8.32%, S 8.34%
Literature References: Prepn: GB 904210; Jacob, Robert, US 3075976 (1962, 1963 both to Rhône-Poulenc). Pharmacology: L. Julon et al., C.R. Seances Soc. Biol. Ses Fil. 160, 1852 (1966). Clinical evaluation as antipsychotic: M. Bourgeois, A.-M. Sicart, Bordeaux Med. 3, 515 (1970).
Properties: Crystalline powder from benzene:cyclohexane (15:85), mp 137-138°.
Melting point: mp 137-138°
Derivative Type: Hydrochloride
Molecular Formula: C22H28N2O2S.HCl
Molecular Weight: 421.00
Percent Composition: C 62.76%, H 6.94%, N 6.65%, O 7.60%, S 7.62%, Cl 8.42%
Properties: LD50 in mice (mg/kg): 115 i.v.; 140 i.p.; 330 s.c.; 310 orally (Julon).
Toxicity data: LD50 in mice (mg/kg): 115 i.v.; 140 i.p.; 330 s.c.; 310 orally (Julon)
Therap-Cat: Antipsychotic.
Keywords: Antipsychotic; Phenothiazines. |