Title: Pipecurium Bromide
CAS Registry Number: 52212-02-9
CAS Name: 4,4¢-[(2b,3a,5a,16b,17b)-3,17-Bis(acetyloxy)androstane-2,16-diyl]bis(1,1-dimethylpiperazinium)dibromide
Additional Names: 4,4¢-(3a,17b-dihydroxy-5a-androstan-2b,16b-ylene)bis(1,1-dimethylpiperazinium)dibromide diacetate; pipecuronium bromide
Manufacturers' Codes: RGH-1106
Trademarks: Arduan (Organon)
Molecular Formula: C35H62Br2N4O4
Molecular Weight: 762.70
Percent Composition: C 55.12%, H 8.19%, Br 20.95%, N 7.35%, O 8.39%
Literature References: Aminosteroid, competitive neuromuscular blocker. Prepn: Z. Tuba et al., DE 2337882 (1974 to Gedeon Richter), C.A. 80, 121210d (1974); Z. Tuba, Arzneim.-Forsch. 30, 342 (1980). Toxicity study: E. Kárpáti, K. Biro, ibid. 346. Series of articles on pharmacology, properties, disposition, pharmacokinetics, safety tests, clinical studies: ibid. 346-394. Determn in human serum: G. Szabo, E. Tassonyi, ibid. 31, 1013 (1981).
Properties: Crystals from methylene dichloride/acetone, mp 262-264° (dec). [a]D25 +8.1° (c = 1 in water). LD50 in mice, rats (mg/kg): 29.7, 172.6 i.v.; 70.6, 449.6 i.p.; 60.5, 455.8 s.c. (Kárpáti, Biro).
Melting point: mp 262-264° (dec)
Optical Rotation: [a]D25 +8.1° (c = 1 in water)
Toxicity data: LD50 in mice, rats (mg/kg): 29.7, 172.6 i.v.; 70.6, 449.6 i.p.; 60.5, 455.8 s.c. (Kárpáti, Biro)
Therap-Cat: Neuromuscular blocking agent.
Keywords: Neuromuscular Blocking Agent; Nondepolarizing Agents. |