Title: Piprozolin
CAS Registry Number: 17243-64-0
CAS Name: [3-Ethyl-4-oxo-5-(1-piperidinyl)-2-thiazolidinylidene]acetic acid ethyl ester
Additional Names: 3-ethyl-4-oxo-5-piperidino-D2,a-thiazolidineacetic acid ethyl ester
Manufacturers' Codes: Gö-919; W-3699
Trademarks: Coleflux (Finadiet); Epsyl (Exa); Probilin (Gecke; Warner-Lambert); Secrebil (Isnardi)
Molecular Formula: C14H22N2O3S
Molecular Weight: 298.40
Percent Composition: C 56.35%, H 7.43%, N 9.39%, O 16.09%, S 10.75%
Literature References: Prepn: G. Satzinger, Ann. 665, 150 (1963); G. Satzinger et al., DE 2414345 (1975 to Goedecke), corresp to US 3971794 (1976 to Warner-Lambert). Metabolism and pharmacokinetics: K. O. Vollmer, F. W. Koss, Arch. Int. Pharmacodyn. Ther. 198, 312 (1972). Mechanism of action: F. W. Koss et al., ibid. 333. Series of articles on synthesis, pharmacology, toxicology and clinical studies: Arzneim.-Forsch. 27, 463-526 (1977). Toxicity data: M. Herrmann et al., ibid. 467.
Properties: Colorless cryst, mp 86-87°. Practically insol in water. Sol in dil aq acids and most organic solvents. uv max (methanol): 245, 285 nm (e 8200, 20000) (Vollmer). LD50 in mice, rats (mg/kg): 1070, 3256 orally (Herrmann).
Melting point: mp 86-87°
Absorption maximum: uv max (methanol): 245, 285 nm (e 8200, 20000) (Vollmer)
Toxicity data: LD50 in mice, rats (mg/kg): 1070, 3256 orally (Herrmann)
Therap-Cat: Choleretic.
Keywords: Choleretic. |