Title: Pyrantel
CAS Registry Number: 15686-83-6
CAS Name: (E)-1,4,5,6-Tetrahydro-1-methyl-2-[2-(2-thienyl)ethenyl]pyrimidine
Molecular Formula: C11H14N2S
Molecular Weight: 206.31
Percent Composition: C 64.04%, H 6.84%, N 13.58%, S 15.54%
Literature References: Prepn: BE 658987 (1965 to Pfizer), C.A. 64, 8192c (1966); Austin et al., Nature 212, 1273 (1966); Kasubrick, McFarland, ZA 6800516; eidem, US 3502661 (1968, 1970 both to Pfizer). Structure-activity studies: McFarland et al., J. Med. Chem. 12, 1066 (1969). Pharmacology and animal trials: Cornwell, Vet. Rec. 79, 590 (1966); Howes, Lynch, J. Parasitol. 53, 1085 (1967); Eyre, J. Pharm. Pharmacol. 22, 26 (1970).
Properties: Crystals from methanol, mp 178-179°.
Melting point: mp 178-179°
Derivative Type: Tartrate
CAS Registry Number: 33401-94-4
Manufacturers' Codes: CP-10423-18
Trademarks: Banminth (Pfizer); Strongid (Pfizer)
Molecular Formula: C11H14N2S.C4H6O6
Molecular Weight: 356.39
Percent Composition: C 50.55%, H 5.66%, N 7.86%, S 9.00%, O 26.94%
Properties: White crystals from hot methanol, mp 148-150°. uv max (water): 312 nm (log e 4.27).
Melting point: mp 148-150°
Absorption maximum: uv max (water): 312 nm (log e 4.27)
Derivative Type: Pamoate
CAS Registry Number: 22204-24-6
Additional Names: Pyrantel embonate
Manufacturers' Codes: CP-10423-16
Trademarks: Cobantril (Pfizer); Combantrin (Pfizer); Helmex (Infectopharm); Helmintox (Innotha); Nemex (Pfizer)
Molecular Formula: C11H14N2S.C23H16O6
Molecular Weight: 594.68
Percent Composition: C 68.67%, H 5.08%, N 4.71%, S 5.39%, O 16.14%
Properties: Tasteless, yellow crystalline powder. Insol in water.
Therap-Cat: Anthelmintic (Nematodes).
Therap-Cat-Vet: Anthelmintic (Nematodes).
Keywords: Anthelmintic (Nematodes). |