Title: Satigrel
CAS Registry Number: 111753-73-2
CAS Name: 4-Cyano-5,5-bis(4-methoxyphenyl)-4-pentenoic acid
Manufacturers' Codes: E-5510
Molecular Formula: C20H19NO4
Molecular Weight: 337.37
Percent Composition: C 71.20%, H 5.68%, N 4.15%, O 18.97%
Literature References: Platelet aggregation inhibitor; inhibits phosphodiesterases and cyclooxygenase-1. Prepn: Y. Yamagishi et al., EP 238973; eidem, US 4978767 (1987, 1990 both to Eisai). Pharmacology: T. Fujimori et al., Arzneim.-Forsch. 37, 1143 (1987); eidem, Cardiovasc. Drug Rev. 9, 264 (1991). Selectivity for cyclooxygenase and phosphodiesterase isoforms: N. Nagakura et al., Biol. Pharm. Bull. 19, 828 (1996). GC-MS determn in plasma: Y. Yamano et al., J. Chromatogr. 528, 199 (1990). Clinical trial to prevent transient ischemic attacks: S. Maruyama et al., Angiology 46, 999 (1995).
Properties: Crystals from ethyl acetate/hexane, mp 124-125°.
Melting point: mp 124-125°
Therap-Cat: Antithrombotic.
Keywords: Antithrombotic; Phosphodiesterase Inhibitor. |