Title: Scillarenin
CAS Registry Number: 465-22-5
CAS Name: (3b)-3,14-Dihydroxybufa-4,20,22-trienolide
Molecular Formula: C24H32O4
Molecular Weight: 384.51
Percent Composition: C 74.97%, H 8.39%, O 16.64%
Literature References: Prepn by adaptive enzymic decompn of proscillaridin A: Stoll et al., Helv. Chim. Acta 34, 2301 (1951); from Urginea burkei Baker, Liliaceae: Zoller, Tamm, ibid. 36, 1744 (1953). Structure: Stoll et al., ibid. 35, 1934 (1952). Toxicity study: Chen, Henderson, J. Pharmacol. Exp. Ther. 111, 365 (1954).
Properties: Prisms from methanol, mp 232-238°. [a]D20 -16.8° (c = 0.357 in methanol); [a]D20 +17.9° (c = 0.39 in chloroform). uv max: 300 nm (log e 3.72). Mean LD i.v. in cats: 0.1567 mg/kg (Chen, Henderson).
Melting point: mp 232-238°
Optical Rotation: [a]D20 -16.8° (c = 0.357 in methanol); [a]D20 +17.9° (c = 0.39 in chloroform)
Absorption maximum: uv max: 300 nm (log e 3.72)
Toxicity data: Mean LD i.v. in cats: 0.1567 mg/kg (Chen, Henderson)
Derivative Type: 3-Acetate
Molecular Formula: C26H34O5
Molecular Weight: 426.55
Percent Composition: C 73.21%, H 8.03%, O 18.75%
Properties: Crystals from methanol, dec 240-243°. [a]D20 -23.4° (c = 1.365 in chloroform).
Optical Rotation: [a]D20 -23.4° (c = 1.365 in chloroform)
Therap-Cat: Cardiotonic.
Keywords: Cardiotonic. |