Title: Stem Cell Factor
Additional Names: Steel factor; mast cell growth factor; kit ligand; SCF
Literature References: Hematopoietic growth factor that interacts with other cytokines to stimulate primitive, undifferentiated blast cells and is particularly important in mast cell and erythroid lineages. The full length, membrane bound protein consists of 248 amino acids that is cleaved to produce a soluble form consisting of 165 residues. The soluble form exists as a glycosylated homodimer; mol wt ~45 kDa. Identification: D. E. Williams et al., Cell 63, 167 (1990); K. M. Zsebo et al., ibid. 195. Review of discovery and bioactivity: D. E. Williams, S. D. Lyman, Prog. Growth Factor Res. 3, 235-242 (1991). Crystal structure of human soluble dimer: Z. Zhang et al., Proc. Natl. Acad. Sci. USA 97, 7732 (2000). Review of biology and clinical potential: I. K. McNiece, R. A. Briddell, J. Leukocyte Biol. 57, 14-22 (1995); J. Glaspy et al., Cancer Chemother. Pharmacol. 38, Suppl., S53-S57 (1996). Review of role in hematopoietic system: L. K. Ashman, Int. J. Biochem. Cell Biol. 31, 1037-1051 (1999); and therapeutic potential: S. Nakagawa, T. Kitoh, Curr. Opin. Hematol. 7, 133-142 (2000).
Derivative Type: Ancestim
CAS Registry Number: 163545-26-4
CAS Name: N-L-Methionyl-1-165-hematopoietic cell growth factor KL (human clone V19.8:hSCF162) dimer
Additional Names: rhSCF
Trademarks: Stemgen (Amgen)
Literature References: Produced in E. coli by recombinant DNA technology. Prepn: K. M. Zsebo et al., EP 423980 (1991 to Amgen). Clinical trial in combination with filgrastim for hematopoietic reconstitution in chemotherapy patients: E. J. Shpall et al., Blood 9, 2491 (1999).
Therap-Cat: Hematopoietic.
Keywords: Hematopoietic. |