Title: Succinylcholine Bromide
CAS Registry Number: 55-94-7
CAS Name: 2,2¢-[(1,4-Dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethylethanaminium] dibromide
Additional Names: bis[2-dimethylaminoethyl]succinate bis[methobromide]; 3,8-dioxadecane-4,7-dione-1,10-bis[trimethylammonium bromide]; suxamethonium bromide
Manufacturers' Codes: IS-370; compd 48/268; LT-1; M & B 2207
Trademarks: Brevidil M (M & B)
Molecular Formula: C14H30Br2N2O4
Molecular Weight: 450.21
Percent Composition: C 37.35%, H 6.72%, Br 35.50%, N 6.22%, O 14.22%
Literature References: Prepd by reacting b-bromoethyl succinate with trimethylamine: Glick, J. Biol. Chem. 137, 357 (1941); Fusco et al., Gazz. Chim. Ital. 79, 129, 837 (1949); Walker, J. Chem. Soc. 1950, 193. Alternate prepns: Phillips, J. Am. Chem. Soc. 71, 3264 (1949); Tammelin, Acta Chem. Scand. 7, 185 (1953).
Properties: Slightly hygroscopic crystals, mp 225°. Freely sol in water or normal saline, giving solns which are very slightly acidic. Aq solns undergo progressive hydrolysis with corresponding loss of activity and increase in acidity. Prepare solns just before using. The rate of this decompn increases with temp and autoclaving or prolonged exposure to warmth should be avoided.
Melting point: mp 225°
Therap-Cat: Neuromuscular blocking agent.
Keywords: Neuromuscular Blocking Agent; Depolarizing Agents. |