Title: Suplatast Tosylate
CAS Registry Number: 94055-76-2
CAS Name: [3-[[4-(3-Ethoxy-2-hydroxypropoxy)phenyl]amino]-3-oxopropyl]dimethylsulfonium salt with 4-methylbenzenesulfonic acid
Additional Names: (±)-[2-[[p-(3-ethoxy-2-hydroxypropoxy)phenyl]carbamoyl]ethyl]dimethylsulfonium p-toluenesulfonate
Manufacturers' Codes: IPD-1151T
Trademarks: IPD (Taiho)
Molecular Formula: C16H26NO4S.C7H7O3S
Molecular Weight: 499.64
Percent Composition: C 55.29%, H 6.66%, N 2.80%, O 22.42%, S 12.84%
Literature References: Selective inhibitor of the IgE antibody response; inhibits interleukin-4 gene expression and mast cell differentiation. Prepn: A. Koda et al., DE 3408708; eidem, US 4556737 (1984, 1985 both to Taiho). Suppression of IL-4 production and the IgE response: Y. Yanagihara et al., Jpn. J. Pharmacol. 61, 23, 31 (1993). Effect on mast cell differentiation: S. Konno et al., Eur. J. Pharmacol. 259, 15 (1994). Series of articles on toxicology: J. Toxicol. Sci. 17, Suppl. 2, 1-205, (1992); C.A. 117, 103839-103846; 103995 (1992). Acute toxicity: K. Yamishita et al., ibid. 1. Clinical evaluation in asthma: J. Tamaoki et al., Lancet 356, 273 (2000).
Properties: Crystals, mp 70-73°. LD50 in male, female mice, male, female rats (mg/kg): 81, 96, 96, 93 i.v.; in mice, rats (g/kg): >12.5, >10 orally (Yamashita).
Melting point: mp 70-73°
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): 81, 96, 96, 93 i.v.; in mice, rats (g/kg): >12.5, >10 orally (Yamashita)
Therap-Cat: Antiallergic; antiasthmatic.
Keywords: Antiallergic; Antiasthmatic (Nonbronchodilator). |