Title: Survivin
Literature References: Mammalian apoptosis inhibitor; member of the IAP (inhibitor of apopotosis protein) family. Selectively overexpressed in common human cancers and correlates with unfavorable prognosis. Also present in embryonic cells but not detectable in normal differentiated tissues. Cytoplasmic, 142 residue protein; mol wt ~16.5 kDa. Expressed during mitosis in a cell cycle-dependent manner and localized to the mitotic spindle. Identification in human cancers: G. Ambrosini et al., Nat. Med. 3, 917 (1997). Developmentally regulated expression in fetal tissue: C. Adida et al., Am. J. Pathol. 152, 43 (1998). Mechanism of action study: F. Li et al., Nature 396, 580 (1998). Crystal structure of murine: S. W. Muchmore et al., Mol. Cell 6, 173 (2000); of human: L. Chantalat et al., ibid. 183; M. A. Verdecia et al., Nat. Struct. Biol. 7, 602 (2000). Determn in urine and clinical use in diagnosis of bladder cancer: S. D. Smith et al., J. Am. Med. Assoc. 285, 324 (2001). |