Title: Thiopeptin
CAS Registry Number: 12609-84-6
Additional Names: Thiofeed
Literature References: Sulfur containing peptide antibiotic complex produced by Streptomyces tateyamensis no. 7906: Miyairi et al., DE 1929355 (1969 to Fujisawa), C.A. 72, 88921w (1970). Consists of the a and b series of thiopeptins A1, A2, A3, A4, and B (major component). Structurally similar to thiostrepton, q.v. Biological and chemical studies: Miyairi et al., Antimicrob. Agents Chemother. 1, 192 (1972). Characterization of thiopeptins B: Miyairi et al., J. Antibiot. 23, 113 (1970); structural studies: Muramatsu et al., ibid. 25, 537 (1972); 30, 383 (1977). Total structures of components: O. D. Hensens, G. Albers-Schönberg, Tetrahedron Lett. 1978, 3649.
Derivative Type: Thiopeptins B
Properties: Faint yellow crystals, mp 219-222° (dec). [a]D23 -80° (c = 1 in chloroform). uv spectrum (methanol): shoulders at 230-250, 295, 305 nm. Sol in dioxane, DMSO, DMF, pyridine, chloroform. Insol in ether, benzene, n-hexane, petr ether, water. Fairly sol in methanol, acetone, ethyl acetate.
Melting point: mp 219-222° (dec)
Optical Rotation: [a]D23 -80° (c = 1 in chloroform)
Absorption maximum: uv spectrum (methanol): shoulders at 230-250, 295, 305 nm
Therap-Cat-Vet: Antibiotic feed additive. |