Title: Thymopentin
CAS Registry Number: 69558-55-0
CAS Name: N-(N-(N-(N2-L-Arginyl-L-lysyl)-L-a-aspartyl)-L-valyl)-L-tyrosine
Additional Names: thymopoietin pentapeptide; TP-5
Manufacturers' Codes: ORF-15244
Trademarks: Immunox (Cilag); Sintomodulina (Italfarmaco); Timunox (Cilag)
Molecular Formula: C30H49N9O9
Molecular Weight: 679.76
Percent Composition: C 53.01%, H 7.27%, N 18.54%, O 21.18%
Literature References: Thymic hormone analog corresponding to residues 32-36 of thymopoietin, q.v., which exhibits the full biological activity of the natural hormone. Synthesis: G. Goldstein et al., Science 204, 1309 (1979); eidem, US 4190646 (1980 to Sloan-Kettering). Bioavailability: T. Audhya, G. Goldstein, Int. J. Pept. Protein Res. 22, 187 (1983). Pharmacology: K. Bolla et al., Int. J. Clin. Pharmacol. Res. 4, 431 (1984). Comparison of biological activity with thymopoietin and splenin: T. Audhya et al., Proc. Natl. Acad. Sci. USA 81, 2847 (1984). Clinical study in treatment of primary immunodeficiencies: F. Aitui et al., Lancet 1, 551 (1983); in AIDS: N. Clumeck et al., Int. J. Clin. Pharmacol. Res. 4, 459 (1984); in rheumatoid arthritis: M. G. Malaise et al., Lancet 1, 832 (1985). Review: E. A. Boyse, Surv. Immunol. Res. 4, 6-10 (1985).
Therap-Cat: Immunoregulator.
Keywords: Immunomodulator. |