Title: TPMPA
CAS Registry Number: 182485-36-5
CAS Name: Methyl (1,2,3,6-tetrahydro-4-pyridinyl)phosphinic acid
Additional Names: (1,2,5,6-tetrahydropyridine-4-yl)methylphosphinic acid
Molecular Formula: C6H12NO2P
Molecular Weight: 161.14
Percent Composition: C 44.72%, H 7.51%, N 8.69%, O 19.86%, P 19.22%
Literature References: Selective antagonist for GABAc receptors. Prepn: Y. Murata et al., Bioorg. Med. Chem. Lett. 6, 2073 (1996); R. Miledi et al., US 5627169 (1997 to Univ. California). Design and in vitro pharmacology: D. Ragozzino et al., Mol. Pharmacol. 50, 1024 (1996). Specificity vs human receptors and alternate synthesis: M. Chebib et al., Eur. J. Pharmacol. 357, 227 (1998). Use as antagonist: A. Rozzo et al., Neuroscience 90, 1085 (1999).
Properties: Off-white solid from ethanol, mp 252-254°. Soly in water 16 mg/ml. Insol in DMSO.
Melting point: mp 252-254°
Use: Neurochemical tool. |