Title: Treprostinil
CAS Registry Number: 81846-19-7
CAS Name: [[(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-2-hydroxy-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl]oxy]acetic acid
Additional Names: 9-deoxy-2¢,9a-methano-3-oxa-4,5,6-trinor-3,7-(1¢,3¢-interphenylene)-13,14-dihydroprostaglandin F1
Molecular Formula: C23H34O5
Molecular Weight: 390.51
Percent Composition: C 70.74%, H 8.78%, O 20.49%
Literature References: Synthetic analog of prostacyclin, q.v. Prepn: P. A. Aristoff et al., GB 2070596; idem, US 4306075 (both 1981 to Upjohn). Pharmacology: R. P. Steffen, M. de la Mata, Prostaglandins Leukotrienes Essen. Fatty Acids 43, 277 (1991). Pharmacokinetics: M. J. McNulty et al., ibid. 159; of intravenous and subcutaneous administration: K. Laliberte et al., J. Cardiovasc. Pharmacol. 44, 209 (2004). RIA determn in plasma: J. W. A. Findlay et al., ibid. 167. Clinical study in pulmonary arterial hypertension: G. Simonneau et al., Am. J. Respir. Crit. Care Med. 165, 800 (2002); by s. c. infusion: R. J. Oudiz et al., Chest 126, 420 (2004); by continuous i.v.: V. F. Tapson et al., ibid. 129, 683 (2006).
Properties: Crystals from ethyl acetate in hexane, mp 121-123°.
Melting point: mp 121-123°
Derivative Type: Sodium salt
CAS Registry Number: 289480-64-4
Manufacturers' Codes: 15AU81; BW15AU; U-62840; UT-15
Trademarks: Remodulin (United Ther.)
Molecular Formula: C23H33NaO5
Molecular Weight: 412.49
Percent Composition: C 66.97%, H 8.06%, Na 5.57%, O 19.39%
Therap-Cat: Antihypertensive.
Keywords: Antihypertensive. |