FDA药品溶出方法数据库
(FDA-Recommended Dissolution Methods Database)
药品通用名称 剂型 USP溶出装置 速度 溶出介质 介质体积 建议取样时间(分钟) 更新日期
Sorafenib Tosylate Tablet II (Paddle) 75 0.1 M HCl with 1% SDS 900 5, 10, 15, 20 and 30 2009/06/10
Sotagliflozin Tablet Develop a dissolution method 2024/08/05
Sotorasib Tablet II (Paddle) 75 120 mg: 50 mM phosphate buffer, pH 6.8 with 0.2% SLS; 320 mg: 50 mM phosphate buffer, pH 6.8 with 0.4% SDS 900 5,10,15, 20 and 30 2023/11/30
Sparsentan Tablet II (Paddle) 60 0.1 N HCl 1000 5, 10, 15, 20, 30, 45 and 60 2024/05/31
Spironolactone Tablet Refer to USP 2008/04/15
Stavudine Capsule Develop a dissolution method 2024/01/03
Succimer Capsule II (Paddle) 50 0.01 N Phosphoric Acid 900 10, 20, 30, 45, 60 and 90 2004/02/20
Sucralfate Suspension II (Paddle) 75 0.1N HCl/0.067 M KCl, pH 1.0 900 10, 20, 30 and 45 2006/03/04
Sucralfate Tablet II (Paddle) 75 0.1 N HCl/0.067 M KCl, pH 1.0 900 15, 30, 45, 60, 180, 240 and 480 2009/04/02
Sucroferric Oxyhydroxide Tablet (Chewable) II (Paddle) 50 0.1 N HCl 900 10, 15, 20, 30, 45 and 60 2017/11/02
Sufentanil Citrate Tablet (Sublingual) II (Paddle) 50 pH 4.5 Acetate Buffer 50 2, 4, 8, 12 and 15 2022/05/12
Sulfadiazine Tablet Refer to USP 2008/07/14
Sulfamethoxazole/Trimethoprim Tablet Refer to USP 2008/01/14
Sulfamethoxazole/Trimethoprim Suspension II (Paddle) 50 1 mL of 0.2 N HCl in water 900 10, 20, 30, 45, 60 and 90 2004/02/25
Sulfasalazine Tablet Refer to USP 2009/12/15
Sulfasalazine Tablet (Delayed Release) Refer to USP 2009/12/15
Sulfisoxazole Acetyl Oral Suspension (Pediatric) II (Paddle) 30 1% SLS in 0.1N HCl 900 15, 30, 45, 60 and 90 2006/08/17
Sumatriptan Succinate Tablet Refer to FDA's Dissolution Guidance, 2018 2020/07/02
Sunitinib Malate Capsule Refer to FDA's Dissolution Guidance, 2018 2020/07/02
Suvorexant Tablet Develop a dissolution method 2023/09/15

数据库说明:

当前数据更新日期:2025年05月30日。
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