美国FDA药品溶出方法数据库

药品通用名称	剂型	USP溶出装置	速度	溶出介质	介质体积	建议取样时间（分钟）	更新日期
Tacrolimus	For Suspension	II (Paddle)	50	Hydroxypropyl Cellulose Solution (1 in 20,000). Adjust to pH 4.5 by Phosphoric Acid		15, 30, 45, 60, 90 and 120	2023/02/09
Tadalafil	Tablet	II (Paddle)	50	0.5% Sodium Lauryl Sulfate	1000	10, 20, 30 and 45	2006/01/26
Tafamidis	Capsule	II (Paddle) with sinker	75	Tier 1 Medium: 0.05M Sodium Phosphate Buffer, pH 6.8 with 1.0% Tween 80; Tier II Medium: 0.05M Sodium Phosphate Buffer, pH 6.8 with 1.0% Tween 80 and enzyme with protease activity as per USP	900	5, 10, 15, 20, 30 and 45	2021/04/22
Tafamidis Meglumine	Capsule	II (Paddle) with sinker	75	Tier 1 Medium: 0.05M Sodium Phosphate Buffer, pH 6.8. Tier 2 Medium: 0.05M Sodium Phosphate Buffer, pH 6.8, and pancreatin with protease activity as per USP	900	5, 10, 15, 20, 30 and 45	2021/04/22
Tafenoquine Succinate	Tablet	II (Paddle)	75	0.01M Sodium phosphate buffer, pH 6.8, with 0.20% w/v of Polysorbate 20	900	5, 10, 20, 30, 45 and 60	2020/08/27
Talazoparib Tosylate	Capsule	II (Paddle) with sinker	75	0.01 N HCl with 0.2% sodium dodecyl sulfate (SDS),	500	10, 15, 20, 30 and 45	2020/08/27
Tamoxifen Citrate	Tablet			Refer to USP			2009/04/02
Tamsulosin HCl	Capsule	II (Paddle)	100	0-2 hours: 0.003% polysorbate 80, pH 1.2 2-8 hours: phosphate buffer, pH 7.2	500	1, 2, 3, 6, 8, and 10 hours	2007/03/26
Tapentadol HCl	Tablet			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Tapentadol HCl	Tablet (Extended Release)	II (Paddle) with sinker	100	0.05 M Phosphate Buffer of pH 6.8, Simulated intestinal fluid (without enzyme)	900	0.5, 1, 2, 3, 4, 6, 8, 10 and 12 hours	2013/10/31
Tasimelteon	Capsule			Refer to FDA's Dissolution Guidance, 2018			2020/07/02
Tasimelteon	Suspension			Refer to FDA's Dissolution Guidance, 2018			2024/05/31
Tazemetostat Hydrobromide	Tablet	II (Paddle)	50	0.01 N HCl	900	5, 10, 15, 20, 30 and 45	2022/05/12
Tedizolid Phosphate	Tablet	II (Paddle)	60	0.05 M phosphate buffer pH 6.8	900	5, 10, 15, 20 and 30	2016/06/02
Tegaserod Maleate	Tablet			Develop a dissolution method			2023/09/15
Telaprevir	Tablet			Develop a dissolution method			2023/09/15
Telbivudine	Tablet	II (Paddle)	50	0.1 N HCl	900	15, 30 and 45	2009/04/02
Telithromycin	Tablet	II (Paddle)	50	0.1 N HCl	900	10, 20, 30 and 45	2007/01/03
Telmisartan	Tablet			Refer to USP			2012/01/05
Temazepam	Capsule			Refer to USP			2008/01/14