FDA药品溶出方法数据库
(FDA-Recommended Dissolution Methods Database)
药品通用名称 剂型 USP溶出装置 速度 溶出介质 介质体积 建议取样时间(分钟) 更新日期
Viloxazine HCl Capsule (Extended Release) II (Paddle) with sinker 50 pH 6.8 Phosphate Buffer 900 1, 2, 4, 6, 8, 10, 12 and 16 hours 2022/07/07
Vismodegib Capsule II (Paddle) 75 0.01 N HCl with 1.0% sodium lauryl sulfate (SLS) 900 10, 15, 20, 30 and 45 2015/05/28
Voclosporin Capsule II (Paddle) 75 0.75% of Polyoxyl 40 hydrogenated castor oil in sodium acetate buffer (22mM), pH 4.5 900 10, 20, 30, 45 and 60 2023/02/09
Vorapaxar Sulfate Tablet II (Paddle) 50 41 mM Na2HPO4, 1.5% Citric Acid, pH 3.0 ± 0.5 900 5, 10, 20, 30, 45 and 60 2015/12/24
Voriconazole Suspension II (Paddle) 50 0.1 N HCl 900 10, 20, 30 and 45 2007/01/03
Voriconazole Tablet II (Paddle) 50 0.1 N HCl 900 10, 20, 30 and 45 2008/11/25
Vorinostat Capsule Develop a dissolution method 2023/09/15
Vortioxetine HBr Tablet II (Paddle) 50 0.1 N HCl 900 10, 15, 20, 30 and 45 2015/05/28
Voxelotor Tablet II (Paddle) 75 50 mM phosphate buffer (pH 6.8) with 2% sodium lauryl sulfate (SLS) 900 5, 10, 20, 30 and 45 2022/07/28
Voxelotor Tablet, for Suspension II (Paddle) 75 50 mM phosphate buffer (pH 6.8) with 2% sodium lauryl sulfate (SLS) 900 5, 10, 15, 20 and 30 2022/07/28
Warfarin Sodium Tablet Develop a dissolution method 2024/01/03
Zafirlukast Tablet II (Paddle) 50 1% w/v Aqueous Sodium Dodecyl Sulfate 1000 10. 30, 30 and 45 2007/10/09
Zalcitabine Tablet Develop a dissolution method 2024/01/03
Zaleplon Capsule Refer to FDA's Dissolution Guidance, 2018 2020/07/02
Zidovudine Tablet Refer to FDA's Dissolution Guidance, 2018 2020/07/02
Zileuton Tablet (Extended Release) Develop a dissolution method 2023/09/15
Zileuton Tablet Develop a dissolution method 2023/09/15
Zinc Acetate Capsule II (Paddle) 50 0.1 N HCl 900 10, 20, 30 and 45 2004/02/19
Ziprasidone HCl Capsule II (Paddle) 75 Tier I: 0.05 M Na phosphate buffer, pH 7.5 + 2% SDS (w/w) Tier II: 0.05 M Na phosphate buffer, pH 7.5 (700ml) + 1% pancreatin. After 15 min. incubation, add 200 mL of phosphate buffer containg 9% SDS 900 10, 20, 30, 45 and 60 2006/03/04
Zolmitriptan Tablet Refer to FDA's Dissolution Guidance, 2018 2020/07/02

数据库说明:

当前数据更新日期:2025年01月08日。
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