HA-1004-药物合成数据库

【药物名称】HA-1004

化学结构式(Chemical Structure):

参考文献No.	49652
标题:	HA-1004
作者:	Koch, H.; Casta馿r, J.
来源:	Drugs Fut 1985,10(10),815

合成路线图解说明: The reaction of 5-isoquinolinesulfonyl chloride (I) with ethyldiamine (II) in methylene chloride gives N-(2-aminoethyl)isoquinoline-5-sulfonamide (III), which is then condensed with S-methylisothiourea sulfate (IV) by means of NaOH at 80 C.

参考文献No.	607996
标题:	Vasodilatory action of HA-1004 [N-(2-guanidinoethyl)-5-isoquinolinesulfonamide], a novel calcium antagonist with no efect on cardiac function
作者:	Asano, T.; Hidaka, H.
来源:	J Pharmacol Exp Ther 1984,231(1),141

合成路线图解说明: The reaction of 5-isoquinolinesulfonyl chloride (I) with ethyldiamine (II) in methylene chloride gives N-(2-aminoethyl)isoquinoline-5-sulfonamide (III), which is then condensed with S-methylisothiourea sulfate (IV) by means of NaOH at 80 C.