Suplatast tosilate, IPD-1151T, IPD, MPD-药物合成数据库

【药物名称】Suplatast tosilate, IPD-1151T, IPD, MPD

化学结构式(Chemical Structure):

参考文献No.	77
标题:	Sulfonium cpds., processes for preparing the cpds. and pharmacological compsns. containing the same
作者:	Hori, M.; Matsuura, N.; Ueda, S.; Yamawaki, I.; Yasumoto, M.; Tada, Y.; Koda, A. (Taiho Pharmaceutical Co., Ltd.)
来源:	CH 659066; DE 3408708; FR 2542312; GB 2137986; JP 1984167564; JP 1984170062; JP 1985152459; US 4556737

合成路线图解说明: The condensation of 3-(methylmercapto)propionyl chloride (I) with 4-(3-ethoxy-2 hydroxypropoxy) aniline (II) by means of triethylamine in DMF gives the corresponding amide (III), which is then treated with methyl p-toluenesulfonate (IV) in dichloromethane.

参考文献No.	72700
标题:	IPD-1151T
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1988,13(11),952

合成路线图解说明: The condensation of 3-(methylmercapto)propionyl chloride (I) with 4-(3-ethoxy-2 hydroxypropoxy) aniline (II) by means of triethylamine in DMF gives the corresponding amide (III), which is then treated with methyl p-toluenesulfonate (IV) in dichloromethane.