【药物名称】FCE-22250
化学结构式(Chemical Structure):
参考文献No.182
标题:Preparation of azinomethyl-rifamycins
作者:Franceschi, G.; Vioglio, S. (Pharmacia Corp.)
来源:FR 2543141; GB 2139619; US 4507295
合成路线图解说明:

The reaction of tert-butylamine (I) with formaldehyde gives N-methylene-tert-butylamine (II), which is condensed with rifamycin SV (III) by means of MnO2 in THF yielding 3-formylrifamycin SV (IV). Finally, this compound is treated with hydrazine and piperidyl chloroformiminium chloride (V) in THF.

参考文献No.85086
标题:FCE-22250
作者:Menichetti, F.; Prous, J.; Casta馿r, J.
来源:Drugs Fut 1989,14(4),311
合成路线图解说明:

The reaction of tert-butylamine (I) with formaldehyde gives N-methylene-tert-butylamine (II), which is condensed with rifamycin SV (III) by means of MnO2 in THF yielding 3-formylrifamycin SV (IV). Finally, this compound is treated with hydrazine and piperidyl chloroformiminium chloride (V) in THF.

参考文献No.106247
标题:Novel rifamycins. IV. 3-Aminomethylazinomethylrifamycins, a new class of rifamycins, endowed with remarkable antibacterial activity
作者:Marsili, L.; Franceschi, G.; Ballabio, M.; Vioglio, S.; Vigevani, A.; Ungheri, D.; Della Bruna, C.; Sanfilippo, A.
来源:J Antibiot 1984,371209-12
合成路线图解说明:

The reaction of tert-butylamine (I) with formaldehyde gives N-methylene-tert-butylamine (II), which is condensed with rifamycin SV (III) by means of MnO2 in THF yielding 3-formylrifamycin SV (IV). Finally, this compound is treated with hydrazine and piperidyl chloroformiminium chloride (V) in THF.

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