【药物名称】Nilutamide, RU-23908, Nilandron, Anandron
化学结构式(Chemical Structure):
参考文献No.45883
标题:1-(3-(4-O-Trifluoromethyl-4-(4-O-nitrophenyl)-4,4-dimethyl)imidazolidines
作者:Perronet, J.; Girault, P.; Bonne, C. (Aventis Pharma SA)
来源:DE 2649925; ES 452746; FR 2329276; FR 7533084; GB 1518444; JP 52057176; US 4097578
合成路线图解说明:

3-Trifluoromethyl-4-nitrophenylisocyanate (I) and 2-amino-2-cyanopropane (II) are condensed. After concentration by distillation under reduced pressure and chromatography of the residue on silica gel (elution with dichloromethane: acetone, 8:2 v/v), the intermediate 1-(3'-trifluoromethyl-4'-nitrophenyl)-4,4-dimethyl-5-imino-2-imidazolidinone) (III) is obtained. This intermediate, in suspension in aqueous hydrochloric acid, is heated, then cooled and poured into water. The precipitate, filtered, washed and dried, is anandron (RU-23908), which can be recrystallized in an ethanolic medium.

参考文献No.49902
标题:Nilutamide
作者:Ojasoo, T.
来源:Drugs Fut 1987,12(8),763
合成路线图解说明:

3-Trifluoromethyl-4-nitrophenylisocyanate (I) and 2-amino-2-cyanopropane (II) are condensed. After concentration by distillation under reduced pressure and chromatography of the residue on silica gel (elution with dichloromethane: acetone, 8:2 v/v), the intermediate 1-(3'-trifluoromethyl-4'-nitrophenyl)-4,4-dimethyl-5-imino-2-imidazolidinone) (III) is obtained. This intermediate, in suspension in aqueous hydrochloric acid, is heated, then cooled and poured into water. The precipitate, filtered, washed and dried, is anandron (RU-23908), which can be recrystallized in an ethanolic medium.

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