Navelbine, Vinorelbine, KW-2307, NVB, Navelbine, Eunades, Navelbine(tartrate)-药物合成数据库

【药物名称】Navelbine, Vinorelbine, KW-2307, NVB, Navelbine, Eunades, Navelbine(tartrate)

化学结构式(Chemical Structure):

参考文献No.	50257
标题:	Navelbine
作者:	Casta馿r, J.; Prous, J.
来源:	Drugs Fut 1986,11(7),575

合成路线图解说明: The reaction of anhydrovinblastine (I) with m-chloroperbenzoic acid in dichloromethane gives anhydrovinblastine-N6-oxide (II), which by reaction with trifluoroacetic anhydride is converted to the bistrifluoroacetate (III). Compound (III) by treatment with THF-water undergoes isomerization to the open bistrifluoroacetate (IV), and cyclization to the desired product.

参考文献No.	700387
标题:	Antitumor compound of the vinblastine group: New method of preparation
作者:	Andrimialisoa, R. Z.; Langlois, N.; Langlois, Y.; Potier, P.
来源:	Tetrahedron 1980,36(20),3053

合成路线图解说明: The reaction of anhydrovinblastine (I) with m-chloroperbenzoic acid in dichloromethane gives anhydrovinblastine-N6-oxide (II), which by reaction with trifluoroacetic anhydride is converted to the bistrifluoroacetate (III). Compound (III) by treatment with THF-water undergoes isomerization to the open bistrifluoroacetate (IV), and cyclization to the desired product.