Probimane, AT-2153, MST-02-药物合成数据库

【药物名称】Probimane, AT-2153, MST-02

化学结构式(Chemical Structure):

参考文献No.	804
标题:	Bis-dioxopiperazine derivs., process for their preparation, antitumor agents comprising them and compsns. containing them
作者:	Ren, Y.-F. (Zenyaku Kogyo Co., Ltd.)
来源:	EP 0125475; JP 1984190976; JP 1985025975; JP 1985069070; US 4737497

合成路线图解说明: Condensation of (rac)-propylene-1,2-diaminetetraacetic acid (I) with formamide gives (rac)-1,2-bis(3,5-dioxopiperazin-1-yl)propane (II). The latter compound is heated with morpholine, and then treated with aqueous formaldehyde. Probimane separates on cooling of the reaction mixture.

参考文献No.	62995
标题:	Probimane
作者:	Ruyun, J.
来源:	Drugs Fut 1988,13(5),418

合成路线图解说明: Condensation of (rac)-propylene-1,2-diaminetetraacetic acid (I) with formamide gives (rac)-1,2-bis(3,5-dioxopiperazin-1-yl)propane (II). The latter compound is heated with morpholine, and then treated with aqueous formaldehyde. Probimane separates on cooling of the reaction mixture.