IDPH-8032-药物合成数据库

【药物名称】IDPH-8032

化学结构式(Chemical Structure):

参考文献No.	50751
标题:	IDPH-8032
作者:	Shridhar, D.R.; Arya, V.P.
来源:	Drugs Fut 1985,10(7),559

合成路线图解说明: The reaction of 6,8-dinitro-2H-1,4-benzoxazine-3(4H)-thione (I) with ethyl carbazate (II) in refluxing ethanol gives 6,8-dinitro-3-(2-ethoxy-carbonyl)hydrazino-2H-1,4-benzoxazine (III), which undergoes ring closure in refluxing o-dichlorobenzene to give the title compound.

合成路线图解说明: The cyclocondensation of 2H-1,4 benzoxazine-3(4H)-thione (IV) with ethyl carbazate (II) in refluxing DMF gives 2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzoxazin-1-one (V), which is nitrated at room temperature with a mixture of concentrated HNO3 and H2SO4.

参考文献No.	700254
标题:	Potential diuretics. Part I. Synthesis of some substituted 2,4-dihydro-1-oxo/thioxo-1,2,4-triazolo[3,4-c][1,4]benzoxazines - Novel diuretic agents
作者:	Shridhar, D.R.
来源:	Indian J Chem 1984,2381279

合成路线图解说明: The reaction of 6,8-dinitro-2H-1,4-benzoxazine-3(4H)-thione (I) with ethyl carbazate (II) in refluxing ethanol gives 6,8-dinitro-3-(2-ethoxy-carbonyl)hydrazino-2H-1,4-benzoxazine (III), which undergoes ring closure in refluxing o-dichlorobenzene to give the title compound.

合成路线图解说明: The cyclocondensation of 2H-1,4 benzoxazine-3(4H)-thione (IV) with ethyl carbazate (II) in refluxing DMF gives 2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzoxazin-1-one (V), which is nitrated at room temperature with a mixture of concentrated HNO3 and H2SO4.