Naftopidil, KT-611, BM-15275, Avishot, Flivas-药物合成数据库

【药物名称】Naftopidil, KT-611, BM-15275, Avishot, Flivas

化学结构式(Chemical Structure):

参考文献No.	39876
标题:	1-[3-(Napht-1-yloxy)-2-hydroxypropyl]-piperazine c
作者:	Thiel, M.; Sponer, G.; Stach, K.; Witte, E.-C.; Roesch, E. (Roche Diagnostics GmbH)
来源:	GB 1445548; US 3997666

合成路线图解说明: The reaction of 1-naphthol (I) with epichlorohydrin (II) in the presence of aqueous sodium hydroxide yields 1-(1-naphthyloxy)-2,3-epoxypropane (III). (III) is then reacted either in alcohol or without any solvent with 1-(2-methoxyphenyl)piperazine (IV).

参考文献No.	51182
标题:	Naftopidil
作者:	Prous, J.; Casta馿r, J.
来源:	Drugs Fut 1987,12(1),31

合成路线图解说明: The reaction of 1-naphthol (I) with epichlorohydrin (II) in the presence of aqueous sodium hydroxide yields 1-(1-naphthyloxy)-2,3-epoxypropane (III). (III) is then reacted either in alcohol or without any solvent with 1-(2-methoxyphenyl)piperazine (IV).