【药物名称】Nedaplatin, NSC-375101D, 254-S, Aqupla
化学结构式(Chemical Structure):
参考文献No.1456
标题:Novel glycolic acid platinum complex and antineoplasticagent
作者:Shiratori, O.; Toya, T.; Aono, K. (Shionogi & Co. Ltd.)
来源:JP 1984222497
合成路线图解说明:

An aqueous solution of diamineplatinum nitrate (I) is passed through an anion exchange resin to give diamineplatinum hydroxide (II), which is then treated with glycolic acid (III) in hot water.

参考文献No.79471
标题:254-S
作者:Casta馿r, J.; Casta馿r, R.M.; Serradell, M.N.
来源:Drugs Fut 1987,12(11),1029
合成路线图解说明:

An aqueous solution of diamineplatinum nitrate (I) is passed through an anion exchange resin to give diamineplatinum hydroxide (II), which is then treated with glycolic acid (III) in hot water.

参考文献No.700479
标题:
作者:Satoi, Y.; Jaracz, E.; Ling, M.; Rico, M.J.; Maher, R.M.; Eichenfield, L.; Fleischer, A.B.
来源:5th Inter Symp Platinum Other Metal Coordin Comp Cancer Chemother (June,29-July,2, Abano Terme) 1987,47(4),E44
合成路线图解说明:

An aqueous solution of diamineplatinum nitrate (I) is passed through an anion exchange resin to give diamineplatinum hydroxide (II), which is then treated with glycolic acid (III) in hot water.

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