Palatrigine, BW A256C-药物合成数据库

【药物名称】Palatrigine, BW A256C

化学结构式(Chemical Structure):

参考文献No.	1851
标题:	1,2,4-Triazines
作者:	Miller, A.A.; Allan, G.; Sawyer, D.A. (Glaxo Wellcome plc)
来源:	EP 0142306; ES 8606304; JP 1985109577; US 4649139

合成路线图解说明: 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) (I) is alkylated with 2-iodopropane in refluxing pentan-2-one. The free base, obtained following treatment of the hydroiodide with methanolic sodium hydroxide, is converted to the title compound with methanolic hydrogen chloride.

参考文献No.	51704
标题:	BW-A256C
作者:	Donoghue, S.; Sawyer, D.; Allan, G.
来源:	Drugs Fut 1987,12(7),621

合成路线图解说明: 3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine (lamotrigine) (I) is alkylated with 2-iodopropane in refluxing pentan-2-one. The free base, obtained following treatment of the hydroiodide with methanolic sodium hydroxide, is converted to the title compound with methanolic hydrogen chloride.