Trecadrine, WAS-4304-药物合成数据库

【药物名称】Trecadrine, WAS-4304

化学结构式(Chemical Structure):

参考文献No.	39663
标题:	New cpds. derived from diphenyl-methylene-ethylamine
作者:	Cirera, X.D.; Bruseghini, L.; Andreoli, R.R.; Irrure, J.P.; Lloveras, P.P. (Sociedad Espa駉la de Especialidades Farmaco-Terap閡ticas SA)
来源:	EP 0132764; US 5112826

合成路线图解说明: The title compound has been synthesized by alkylation of ephedrine (II) with the chloroethylidene derivative (I).

参考文献No.	39664
标题:	Preparation of a deriv. of 2-amino-1-phenylpropan-1-ol
作者:	Andreoli, R.; Forn? E.; Cepero, R. (Sociedad Espa駉la de Especialidades Farmaco-Terap閡ticas SA)
来源:	ES 2017278

合成路线图解说明: In a related procedure, aldehyde (III) was condensed with ephedrine (II) under azeotropic removal of water, affording oxazolidine (IV). Subsequent reduction of (IV) using NaBH4 furnished the title compound.