Tioxamast, F-1865-药物合成数据库

【药物名称】Tioxamast, F-1865

化学结构式(Chemical Structure):

参考文献No.	13478
标题:	4-Phenyl-2-thiazolyloxamate derivs., method for their preparation and their application in the treatment of asthma
作者:	Casadio, S.; Cousse, H.; Tarayre, J.P.; Mouzin, G. (Pierre Fabre S.A.)
来源:	EP 0006368; ES 481633; FR 2429210; JP 55002684; US 4246271

合成路线图解说明: The cyclization of p-methoxyacetophenone (I) with thiourea (II) by means of SO2Cl2 gives 4-(p-methoxyphenyl)-2-aminothiazole (III), which is then reacted with ethoxalyl chloride (IV) in presence of a base to afford F-1865.

参考文献No.	127621
标题:	TIOXAMAST
作者:	Tarayre, J.P.; Bonnaud, B.
来源:	Drugs Fut 1990,15(5),469

合成路线图解说明: The cyclization of p-methoxyacetophenone (I) with thiourea (II) by means of SO2Cl2 gives 4-(p-methoxyphenyl)-2-aminothiazole (III), which is then reacted with ethoxalyl chloride (IV) in presence of a base to afford F-1865.