Cefuzonam sodium, CL-118523(free acid), LJC-10305, L-105, MTC.Na, CL-251931(free acid), Cosmosin-药物合成数据库

【药物名称】Cefuzonam sodium, CL-118523(free acid), LJC-10305, L-105, MTC.Na, CL-251931(free acid), Cosmosin

化学结构式(Chemical Structure):

参考文献No.	62367
标题:	Bisfentidine
作者:	Scarpignato, C.
来源:	Drugs Fut 1988,13(2),110

合成路线图解说明: The condensation of 7-aminocephalosporanic acid (I) with sodium 1,2,3-thiadiazole-5-thiolate (II) gives 7-amino-3-[1,2,3-thiadiazol-5-ylmethyl]-3-cephem-4-carboxylic acid (III). Following the first step, condensation of (III) with 2-(2-chloroacetamidothiazol-4-yl)-sulfanyl-(Z)-2-methoxyiminoacetyl chloride hydrochloride (IV) followed by deprotection with sodium N-methyldithiocarbamate (V) affords sodium 7-[(Z)-2-(2-aminothiazol-4yl)-2-(methoxyimino)acetamido)-3-(1,2,3-thiadiazol-5-ylsulfanylmethyl)-3-cephem-4-carboxylate.

参考文献No.	900145
标题:	Antiulcerogenic amidine derivatives of 2-substituted 4-phenylimidazole.
作者:	Bietti, G.; Cereda, E.; Donetti, A.; Giachetti, A.; Pagani, F. (Angelini Inst SpA)
来源:	EP 0131973; GB 2149395; US 4649150

合成路线图解说明: The condensation of 7-aminocephalosporanic acid (I) with sodium 1,2,3-thiadiazole-5-thiolate (II) gives 7-amino-3-[1,2,3-thiadiazol-5-ylmethyl]-3-cephem-4-carboxylic acid (III). Following the first step, condensation of (III) with 2-(2-chloroacetamidothiazol-4-yl)-sulfanyl-(Z)-2-methoxyiminoacetyl chloride hydrochloride (IV) followed by deprotection with sodium N-methyldithiocarbamate (V) affords sodium 7-[(Z)-2-(2-aminothiazol-4yl)-2-(methoxyimino)acetamido)-3-(1,2,3-thiadiazol-5-ylsulfanylmethyl)-3-cephem-4-carboxylate.