【药物名称】Lorglumide, CR-1409
化学结构式(Chemical Structure):
参考文献No.2692
标题:Derivatives of glutamic acid and aspartic acid
作者:Rovati, L.; Makovec, F.; Senin, P.; Chiste', R. (Rotta Research Laboratorium SpA)
来源:AU 8544109; BE 0902726; CH 674203; DE 3522506; ES 8604859; FR 2566397; GB 2160869; JP 1986044855; US 4791215
合成路线图解说明:

The condensation of glutamic acid (I) with 3,4-dichlorobenzoyl chloride (II) by means of Na2CO3 in water gives N-(3,4-dichlorobenzoyl)glutamic acid (III), which is treated with acetic anhydride in refluxing isopropyl ether to afford N-(3,4-dichlorobenzoyl)glutamic anhydride (IV). Finally, this compound is treated with dipentylamine (V) in water.

参考文献No.77902
标题:Lorglumide
作者:Casta馿r, J.; Serradell, M.N.; Casta馿r, R.M.
来源:Drugs Fut 1987,12(9),851
合成路线图解说明:

The condensation of glutamic acid (I) with 3,4-dichlorobenzoyl chloride (II) by means of Na2CO3 in water gives N-(3,4-dichlorobenzoyl)glutamic acid (III), which is treated with acetic anhydride in refluxing isopropyl ether to afford N-(3,4-dichlorobenzoyl)glutamic anhydride (IV). Finally, this compound is treated with dipentylamine (V) in water.

参考文献No.604511
标题:Differentiation of central and peripheral cholecystokinin receptors by new glutaramic acid derivatives with cholecystokinin-antagonistic activity
作者:Rovati, L.C.; Chiste, R.; Bani, M.; Revel, L.; Makovec, F.; Rovati, L.A.
来源:Arzneim-Forsch Drug Res 1986,36(1),98-102
合成路线图解说明:

The condensation of glutamic acid (I) with 3,4-dichlorobenzoyl chloride (II) by means of Na2CO3 in water gives N-(3,4-dichlorobenzoyl)glutamic acid (III), which is treated with acetic anhydride in refluxing isopropyl ether to afford N-(3,4-dichlorobenzoyl)glutamic anhydride (IV). Finally, this compound is treated with dipentylamine (V) in water.

参考文献No.604512
标题:New glutaramic acid derivatives with potent competitive and specific cholecystokinin-antagonistic activity
作者:Chiste, R.; Makovec, F.; Rovati, L.A.; Pacini, M.A.; Bani, M.; Setnikar, I.
来源:Arzneim-Forsch Drug Res 1985,35(7),1048-1051
合成路线图解说明:

The condensation of glutamic acid (I) with 3,4-dichlorobenzoyl chloride (II) by means of Na2CO3 in water gives N-(3,4-dichlorobenzoyl)glutamic acid (III), which is treated with acetic anhydride in refluxing isopropyl ether to afford N-(3,4-dichlorobenzoyl)glutamic anhydride (IV). Finally, this compound is treated with dipentylamine (V) in water.

参考文献No.700495
标题:
作者:Zrenner, E.; Laties, A.M.
来源:Eur J Med Chem - Chim Ther 1986,21(1),9-20
合成路线图解说明:

The condensation of glutamic acid (I) with 3,4-dichlorobenzoyl chloride (II) by means of Na2CO3 in water gives N-(3,4-dichlorobenzoyl)glutamic acid (III), which is treated with acetic anhydride in refluxing isopropyl ether to afford N-(3,4-dichlorobenzoyl)glutamic anhydride (IV). Finally, this compound is treated with dipentylamine (V) in water.

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