【药物名称】NSC-378901, IDX, I-DOX, FCE-21954, Iodo-Dox
化学结构式(Chemical Structure):
参考文献No.2693
标题:4'-Iododerivatives of anthracycline glycosides
作者:Suarato, A.; Penco, S.; Casazza, A.M.; Arcamone, F. (Pharmacia Corp.)
来源:BE 0892943; DE 3214559; FR 2525225; GB 2118540; JP 58183698; US 4438105
合成路线图解说明:

The reaction of 4'-epi-N-trifluoroacetyldaunorubicin (I) with trifluoro methanesulfonic anhydride gives the corresponding 4'-O-triflate (II), which is converted to 4'-deoxy-4'-iodo-N-trifluoroacetyldaunorubicin (III). The hydrolysis of (III) with NaOH affords 4'-deoxy-4'-iododaunorubicin (IV), which is finally brominated with Br2 and hydrolyzed with aqueous sodium formate.

参考文献No.45882
标题:Process for the preparation of 4'-deoxy-daunorubicin and 4'-deoxy-doxorubicin
作者:Suarato, A.; Penco, S.; Arcamone, F. (Pharmacia Corp.)
来源:EP 0048967; IT 1211116; US 4345070
合成路线图解说明:

The reaction of 4'-epi-N-trifluoroacetyldaunorubicin (I) with trifluoro methanesulfonic anhydride gives the corresponding 4'-O-triflate (II), which is converted to 4'-deoxy-4'-iodo-N-trifluoroacetyldaunorubicin (III). The hydrolysis of (III) with NaOH affords 4'-deoxy-4'-iododaunorubicin (IV), which is finally brominated with Br2 and hydrolyzed with aqueous sodium formate.

参考文献No.117486
标题:FCE-21954
作者:Casta馿r, R.M.; Serradell, M.N.; Nadhestani, A.N.; Casta馿r, J.
来源:Drugs Fut 1987,12(9),849
合成路线图解说明:

The reaction of 4'-epi-N-trifluoroacetyldaunorubicin (I) with trifluoro methanesulfonic anhydride gives the corresponding 4'-O-triflate (II), which is converted to 4'-deoxy-4'-iodo-N-trifluoroacetyldaunorubicin (III). The hydrolysis of (III) with NaOH affords 4'-deoxy-4'-iododaunorubicin (IV), which is finally brominated with Br2 and hydrolyzed with aqueous sodium formate.

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