【药物名称】D-18954
化学结构式(Chemical Structure):
参考文献No.63032
标题:D-18954
作者:Schneider, M.A.; Sch鰊enberger, H.; Schwarz, W.; Hartmann, R.W.; Engel, J.
来源:Drugs Fut 1988,13(8),720
合成路线图解说明:

The synthesis of D-18954 is performed using dimethyl(2-fluoro-4-methoxy-phenyl)carbinol (I) as educt. The tertiary alcohol (I) can be obtained by Grignard reaction of 2-fluoro-4-methoxyacetophenone with methyl magnesium iodide. The dibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3-LiAlH4, according to the method of McMurry and Silvestri. The cleavage of the methoxy groups is accomplished with BBr3 and gives D-18954.

参考文献No.87834
标题:Ring-substituted 1,1,2,2-tetraalkilated 1,2-bis(hydroxyphenyl)-ethanes. 4. Synthesis, estrogen receptor binding afinity of simetrically disubstituted 1,1,2,2,-tetramethyl-1,2-bis(hydroxyphenyl)ethanes
作者:Hartmann, R.W.; et al.
来源:J Med Chem 1985,28(28),1295
合成路线图解说明:

The synthesis of D-18954 is performed using dimethyl(2-fluoro-4-methoxy-phenyl)carbinol (I) as educt. The tertiary alcohol (I) can be obtained by Grignard reaction of 2-fluoro-4-methoxyacetophenone with methyl magnesium iodide. The dibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3-LiAlH4, according to the method of McMurry and Silvestri. The cleavage of the methoxy groups is accomplished with BBr3 and gives D-18954.

参考文献No.547071
标题:Simplified method for the titanium (II)-induced coupling of allylic and benzylic alcohols
作者:Silvestri, M.A.; McMurry, J.E.
来源:J Org Chem 1975,402687
合成路线图解说明:

The tertiary alcohol (I) can be obtained by Grignard reaction of methyl 4-methoxybenzoate with methylmagnesium iodide. The bibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3 - LiAlH4, according to the method of McMurry and Silvestri. The cleavage of the methoxy groups is performed with BBr3 and gives tetramethylHES.

合成路线图解说明:

The synthesis of D-18954 is performed using dimethyl(2-fluoro-4-methoxy-phenyl)carbinol (I) as educt. The tertiary alcohol (I) can be obtained by Grignard reaction of 2-fluoro-4-methoxyacetophenone with methyl magnesium iodide. The dibenzyl derivative (II) is prepared by reductive coupling of (I) using TiCl3-LiAlH4, according to the method of McMurry and Silvestri. The cleavage of the methoxy groups is accomplished with BBr3 and gives D-18954.

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